What do we know? We know that in migraine, there's a hyper-dilation of the blood vessels, a hyper-dilation of the very little portals that exist in the brain and around the brain that are going to cause the pain—they're going to activate those sensory neurons, those nociceptors—that will then give us the experience of extreme headache and migraine. So, taking an aspirin or something like it for migraine, in some cases, is the worst possible choice.