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The higher the peak in dopamine and the faster the rise to that peak, the further below baseline the dopamine drops after the drug wears off. In the case of cocaine, it's a very fast and very large rise in dopamine followed by a steep drop and very deep trough in dopamine below
baseline.
Andrew Huberman
The Higher the Dopamine Peak, the Lower the Trough; Here's an Example With Cocaine
Leverage Dopamine to Overcome Procrastination & Optimize Effort
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