There are studies where healthy young men drink equivalent of, you know, 12 oz. soda, and their inflammatory biomarkers increased by 100% within, like, 24 hours. And that is substantial, because inflammation ... is not isolated to the immune system. Immune cells are creating a lot of these inflammatory cytokines, but those are then signaling to our brain, and they play a role in depression; they play a role in what people call brain fog.