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Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan
STEM-Talk
Go to Podcast Page
Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan
STEM-Talk
Go to Podcast Page
STEM-Talk
·
44 Clips
·
Jan 28, 2020
Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan
STEM-Talk
0 Clips
·
Jan 28, 2020
Top Moments
One of the best predictors of mortality is cardiorespiratory
fitness.
To Extend Your Healthspan, Exercise to Improve Cardiorespiratory Fitness
Aging is the greatest risk factor for nearly every chronic disease and morbidity that people
face.
Adam is Studying the Effectiveness of Rapamycin & Metformin in Delaying Osteoarthritis
Metformin mitigates the exercise-induced improvements in insulin sensitivity and cardiorespiratory fitness through its inhibition of skeletal muscle mitochondrial adaptations.
Adam Expands on His Finding: Metformin Blunts the Beneficial Effects of Exercise
No matter what, exercise is important ... Exercise is a valuable and effective strategy to improve our
health.
Metformin Blunts Exercise's Beneficial Effect on Insulin Sensitivity
Intros & Ads
STEM-Talk Intro
Dawn & Ken Intro
Dawn Introduces Dr. Adam Konopka
Ken Reads This Episode's Winning STEM-Talk Review
Ken Introduces Dr. Adam Konopka
STEM-Talk Intro
Dawn Introduces Her Co-Host, Ken Ford, and Dr. Adam Konopka
Clips
1
Why Adam Decided to Establish His Lab at the University of Illinois
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2
How Adam Became Interested in Competitive Swimming
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3
Adam's Interest in Competitive Swimming Led Him to Major in Exercise Science
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4
Adam Minored in Entrepreneurship Because He Wanted to Start His Own Business
business
entrepreneurship
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5
Adam's First Research Experience Was Focused on the Health Benefits of Exercise
exercise
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6
Adam Once Studied Muscle Mass Loss in Astronauts
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7
Elevated Mitochondrial Reactive Oxygen Species Production May Reduce Insulin Sensitivity
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8
Exercise Reduces Mitochondrial Defects Associated with Obesity and Insulin Resistance
exercise
obesity
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9
Adam's Research Aims to Translate Cell Culture Findings to Improve Human Health
glucose
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10
Metformin Doesn't Inhibit Glucagon-Stimulated Glucose Production
glucose
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11
While at CSU, Adam Studied the Joint Effect of Metformin and Exercise on Metabolic Health
exercise
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12
Adam is Studying the Effectiveness of Rapamycin & Metformin in Delaying Osteoarthritis
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13
Adam is Studying How Rapamycin Inhibits mTOR in Muscle
muscle
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14
Adam Has Been Studying the Interaction of Exercise & Metformin Since His Post-Doc
exercise
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15
Adam Expands on His Finding: Metformin Blunts the Beneficial Effects of Exercise
exercise
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16
Metformin Blunts Exercise's Beneficial Effect on Insulin Sensitivity
exercise
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17
The More Metabolically Unhealthy, the Greater Potential Benefits from Exercise & Metformin
exercise
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18
Adam Plans to Study Metformin's Effects on a Range of Metabolically Healthy Individuals
exercise
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19
STEM-Talk Interlude
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20
Is it Possible to Pulse Metformin Intake to Limit its Adverse Effects on Exercise?
exercise
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21
The Higher Your Type 2 Diabetes Risk, the Less Metformin Inhibits Exercise's Beneficial Effects
exercise
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22
Metformin Inhibits Exercise-Induced Improvements in Mitochondrial Respiration
exercise
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23
The TAME Trial Isn't Designed to Determine Whether Metformin Extends Healthspan
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24
Ken Wishes the TAME Trial Utilzied Rapamycin Instead of Metformin
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25
Adam Believes a Metformin Trial in Healthy Individuals is Warranted
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26
Metformin May Only Extend Healthspan in Individuals at Risk for Type 2 Diabetes
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27
How Would Adam Design a Healthspan-Extending Intervention Trial?
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28
If Adam Were to Study Metformin's Effect on Healthspan, How Would He Adjust for Diet & Lifestyle Variables?
exercise
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29
Will Pharmacological Methods Prove More Effective at Extending Healthspan & Lifespan Than Exercise?
exercise
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30
PPAR-D Agonists Are a Class of Drugs That Mimic Exercise's Pharmacological Effects
exercise
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31
To Extend Your Healthspan, Exercise to Improve Cardiorespiratory Fitness
exercise
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32
Adam's Exercise Routine Includes Lots of Endurance Running & Biking
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33
How Endurance Training Changed Adam's Fast-Twitch/Slow-Twitch Muscle Profile
muscle
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34
Even with a Young Child, Adam & His Wife Exercise in Their Spare Time
running
child
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35
Adam, Ken, & Dawn Outro
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36
Dawn & Ken Outro
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37
Rate & Review STEM-Talk
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